"Iodine_I_131_Monoclonal_Antibody_8H9"^^ . "C1541591"^^ . "Pharmacologic Substance"^^ . "380753"^^ . "Iodine I 131 Monoclonal Antibody 8H9"^^ . "C48400"^^ . "Iodine I 131 Monoclonal Antibody 8H9"^^ . "380753"^^ . "Iodine I 131 Monoclonal Antibody 8H9PTNCI" . . "Iodine I 131 MOAB 8H9SYNCI" . . "A radioimmunoconjugate consisting of the iodine 131-radiolabeled murine IgG1 monoclonal antibody 8H9 directed against the surface immunomodulatory glycoprotein 4Ig-B7-H3 with potential radioimaging and radioimmunotherapeutic uses. Iodine I 131 monoclonal antibody 8H9 binds to 4Ig-B7-H3 (human B7-H3 with 4 Ig-like domains) and may be used to radioimage and/or destroy tumor cells that express tenascin. 4Ig-B7-H3 inhibits T-cell activation and the production of effector cytokines such as interferon-gamma and interleukin-4; it is expressed on the cell membranes of a wide variety of tumors of neuroectodermal, mesenchymal and epithelial origin and is highly expressed on monocyte-derived dendritic cells (mdDCs). In vitro, it has been shown that monoclonal antibody-mediated masking of 4Ig-B7-H3 on neuroblastoma cells resulted in the enhancement of natural killer (NK)-mediated lysis of target cells.NCI" .