"FDA"^^ . "RemsedBRNCI" . "The hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone.NCI" . "Promethazine HClPTDCP30446" . "231688"^^ . "39567"^^ . "ProviganBRNCI" . "58-33-3"^^ . "C17H20N2S.HCl"^^ . "Promethazine HydrochloridePTDCP01024" . "CHEBI:8462"^^ . "C45907"^^ . "Promethazine HydrochloridePTNCI" . . "Organic Chemical"^^ . . "39567"^^ . "Promethazine Hydrochloride"^^ . . "N-(2-Dimethylaminopropyl-1)phenothiazine HydrochlorideSNNCI" . "C0591971"^^ . "R61ZEH7I1I"^^ . "Pharmacologic Substance"^^ . . "Promethazine Hydrochloride"^^ . . . "AnerganBRNCI" . "Promethazine_Hydrochloride"^^ . . "PROMETHAZINE HYDROCHLORIDEPTFDAR61ZEH7I1I" . "Zipan-50BRNCI" . "PhenerganBRNCI" .