"C0012750"^^ . . "Distamycin_Antibiotic"^^ . . . "DistamycinsSYNCI" . "Distamycin Antineoplastic Antibiotic"^^ . . "Distamycin Antineoplastic Antibiotic"^^ . "Chemical Viewed Functionally"^^ . "An antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription. In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities.NCI" . "Distamycin Antineoplastic AntibioticPTNCI" . "C446"^^ .