"A drug used to treat metastatic or locally advanced breast cancer that has not improved after treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixempra stops the growth of tumor cells by blocking cell division. It is a type of epothilone analog.NCI-GLOSS" . . _:b684465 . "(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dionePTDCP50584" . "Azaepothilone BSYNCI" . "metastatic or locally advanced breast cancer."^^ . "219989-84-1"^^ . "FDA"^^ . _:b684461 . _:b684462 . _:b684461 . . _:b684463 . _:b684462 . . _:b684462 . _:b684463 . _:b684464 . _:b684465 . "Breast cancer; Endometrial cancer; Germ cell tumors; Head and Neck cancer; Leukemia; Lymphoma; Prostate cancer; Recurrent glioma; Small intestine cancer; Urinary tract cancer; Unspecified solid tumors"^^ . _:b684461 . . "Ixabepilone"^^ . "Ixabepilone"^^ . "C1135132"^^ . "ixabepilonePTNCI-GLOSSCDR0000367463" . "710428"^^ . "K27005NP0A"^^ . _:b684464 . "37860"^^ . "C27H42N2O5S"^^ . "EpothiloneSYNCI" . _:b684465 . "IxabepilonePTNCI" . . "IxempraPTNCI-GLOSSCDR0000574038" . "C37452"^^ . "37860"^^ . _:b684462 . . _:b684465 . _:b684463 . _:b684464 . "BMS-247550PTNCI-GLOSSCDR0000044891" . _:b684463 . "BMS 247550CNNCI" . "BMS247550CNNCI" . "Epothilone-B BMS 247550SYNCI" . "CHEBI:63605"^^ . "Pharmacologic Substance"^^ . "An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.NCI" . _:b684461 . "IXABEPILONEPTFDAK27005NP0A" . "Ixabepilone"^^ . "(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dioneSNNCI" . _:b684464 . "IxempraBRNCI" . "BMS-247550CNNCI" .