"Cholera Toxin"^^ . . "Hazardous or Poisonous Substance"^^ . "Amino Acid, Peptide, or Protein"^^ . "9012-63-9"^^ . "C0008356"^^ . . "Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia; A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04)NCI" . "Cholera_Toxin"^^ . "C368"^^ . . "Cholera ToxinPTNCI" . . "Cholera Toxin"^^ .