. "camptothecinPTNCI-GLOSSCDR0000045181" . "39173"^^ . "Organic Chemical"^^ . "CAMPTOTHECINPTFDAXT3Z54Z28A" . "Camptothecin"^^ . . "Camptothecin"^^ . "20-(S)-camptothecineSYNCI" . "(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dioneSNNCI" . "An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.NCI-GLOSS" . "21, 22-Secocamptothecin-21-oic acid lactoneSYDTPNSC0094600" . "94600"^^ . "39173"^^ . "FDA"^^ . "Camptothecin"^^ . "(+)-CamptothecinSYNCI" . "20(S)-CamptothecineSYDTPNSC0094600" . . "1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI)SNNCI" . "7689-03-4"^^ . "An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)NCI" . "(+)-CamptothecinPTDCP09054" . "C20H16N2O4"^^ . "C0006812"^^ . "C338"^^ . "CHEBI:27656"^^ . "camptothecineSYNCI" . "21, 22-secocamptothecin-21-oic acid lactoneSNNCI" . . . . "CamptothecinPTNCI" . "XT3Z54Z28A"^^ . "Pharmacologic Substance"^^ .