"Pharmacologic Substance"^^ . "Timolol MaleatePTNCI" . "TIMOLOL MALEATEPTFDAP8Y54F701R" . "26921-17-5"^^ . . "The maleate salt form of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis.NCI" . _:b719848 . . "Timolol_Maleate"^^ . "P8Y54F701R"^^ . . "C0087093"^^ . "C29501"^^ . _:b719848 . . "FDA"^^ . "Timolol Maleate"^^ . "CHEBI:9600"^^ . _:b719848 . _:b719848 . "Timolol Maleate"^^ . "C13H24N4O3S.C4H4O4"^^ . . "Timolol maleatePTDCP32066" . . .