"Metoprolol succinatePTDCP32069" . _:b693009 . "The succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol succinate antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation, including vasoconstriction, aldosterone secretion.NCI" . "Toprol XLBRNCI" . . "Metoprolol Succinate"^^ . "Organic Chemical"^^ . _:b693009 . "2C15H25NO3.C4H6O4"^^ . _:b693009 . . "98418-47-4"^^ . "Metoprolol Succinate"^^ . "Metoprolol_Succinate"^^ . "Pharmacologic Substance"^^ . "C0724633"^^ . "METOPROLOL SUCCINATEPTFDATH25PD4CCB" . . . "Metoprolol SuccinatePTNCI" . . . . "TH25PD4CCB"^^ . "C29254"^^ . _:b693009 . "FDA"^^ .