_:b647807 . "AZAABNCI" . "FDA"^^ . _:b647807 . "A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.NCI" . "Pharmacologic Substance"^^ . "AZTPABNCI" . "AzathioprineSYNCITCGA" . "Nucleic Acid, Nucleoside, or Nucleotide"^^ . "39084"^^ . . . "Azathioprine"^^ . _:b647807 . . "Azathioprine"^^ . "CHEBI:2948"^^ . "C0004482"^^ . "446-86-6"^^ . . "An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)MSH2002_06_01" . "AZATHIOPRINEPTFDAMRK240IY2L" . "6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purineSNNCI" . "AzathioprinePTNCI" . "Azathioprine"^^ . "C290"^^ . . . "6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purinePTDCP00948" . _:b647807 . "C9H7N7O2S"^^ . . . "MRK240IY2L"^^ .