"Benazepril HClSYNCI" . "FDA"^^ . "CGS14824ACNNCI" . "C28862"^^ . "Pharmacologic Substance"^^ . "C0770917"^^ . . "C24H28N2O5.ClH"^^ . "Benazepril Hydrochloride"^^ . "Benazepril Hydrochloride"^^ . "LotensinBRNCI" . . "86541-74-4"^^ . . "BENAZEPRIL HYDROCHLORIDEPTFDAN1SN99T69T" . "Benazepril HydrochloridePTNCI" . . . "Benazepril HydrochloridePTDCP32055" . . "N1SN99T69T"^^ . "Benazepril_Hydrochloride"^^ . "The hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.NCI" . "Organic Chemical"^^ .