. "C1511078"^^ . "Bcl-Xs Adenovirus Vaccine"^^ . "C28860"^^ . "Bcl-Xs Adenovirus Vaccine"^^ . "Bcl-Xs_Adenovirus_Vaccine"^^ . "A vaccine consisting of replication-defective recombinant adenovirus that encodes for Bcl-Xs with potential antineoplastic activity. Vaccination with Bcl-Xs adenovirus vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in decreased tumor growth while leaving normal cells unaffected. Bcl-Xs block the function of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid tumors and promote cancer cell survival by inhibiting apoptosis. (NCI04)NCI" . . "Immunologic Factor"^^ . "Bcl-Xs Adenovirus VaccinePTNCI" . "689513"^^ . "Pharmacologic Substance"^^ .