_:b723091 . "Monoclonal Antibody Anti-Avb3 IntegrinSYNCI" . "Vitaxin-2"^^ . "Vitaxin 2SYNCI" . _:b723091 . "C1523981"^^ . "C2734"^^ . _:b723091 . "Vitaxin-2"^^ . . "Amino Acid, Peptide, or Protein"^^ . "Vitaxin-2"^^ . "A modified version of Vitaxin, a humanized monoclonal IgG1 antibody to alpha(v)beta(3)integrin. Exhibiting improved affinity to alpha(v)beta(3)integrin compared to first-generation Vitaxin, Vitaxin-2 blocks the binding of ligands, such as vitronectin, to alpha(v)beta(3) integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)NCI" . . _:b723091 . "Pharmacologic Substance"^^ . . "Vitaxin-2PTNCI" .