. "St. John's wortPTNCI-GLOSSCDR0000044957" . "St John's WortSYNCI" . "ST. JOHN'S WORTPTFDAUFH8805FKA" . "St. John's Wort"^^ . "An herbal extract prepared from the plant Hypericum perforatum (St. John's wort) with photodynamic, antineoplastic, and antidepressant activities. Hypericin, one of the active compounds found in Hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines. Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs.NCI" . . "84082-80-4"^^ . "Minor Depression; Social Phobia; Use with Docetaxel in Unresectable Solid Tumors."^^ . . "37989"^^ . "An herbal product sold as an over-the-counter treatment for depression. It is being studied for its ability to lessen certain side effects of cancer treatment.NCI-GLOSS" . "St. John's Wort"^^ . "Hypericum Perforatum ExtractSYNCI" . . "37989"^^ . "Pharmacologic Substance"^^ . "C2589"^^ . "hypericum perforatumPTNCI-GLOSSCDR0000044462" . "C0813171"^^ . "UFH8805FKA"^^ . "FDA"^^ . "Hypericum_Perforatum"^^ . "St. John's WortPTNCI" .