. "FicusinSYNCI" . "CHEBI:27616"^^ . . "37899"^^ . "37899"^^ . "217989"^^ . "psoralenPTNCI-GLOSSCDR0000044900" . . "PsoralenPTNCI" . "C11H6O3"^^ . "C2586"^^ . "Organic Chemical"^^ . "PsoralenSYDTPNSC0404562" . "C0016072"^^ . "66-97-7"^^ . . . "Psoralen"^^ . "PSORALENPTFDAKTZ7ZCN2EX" . . . "KTZ7ZCN2EX"^^ . "Pharmacologic Substance"^^ . "6-hydroxy-5-benzofuranacrylic Acid deta-lactonSNNCI" . "Psoralen"^^ . "A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids.NCI" . "Psoralen"^^ . "A substance from plants that is sensitive to light (or can be activated by light). Psoralens are used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. They are also being studied in the treatment of graft-versus-host disease. Psoralen is a type of furocoumarin. An example of a psoralen is methoxsalen.NCI-GLOSS" . "Psoriasis; T-cell Lymphoma-Cutaneous; Vitiligo"^^ . "PSORALENSYDTPNSC0217989" . "FDA"^^ .