"MKC-1SYNCI" . . "DNZ11VPY7Q"^^ . "MKC-1PTFDADNZ11VPY7Q" . "MKC-1"^^ . "MKC-1"^^ . "Ro_31-7453"^^ . . "Organic Chemical"^^ . "Pharmacologic Substance"^^ . "C22H16N4O4"^^ . "Ro 31-7453CNNCI" . . "Ro 31-7453PTNCI-GLOSSCDR0000046177" . "A substance that is being studied in the treatment of cancer. It may prevent cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors.NCI-GLOSS" . "125313-92-0"^^ . "C0796487"^^ . "An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus.NCI" . . "C2507"^^ . "FDA"^^ . "R440CNNCI" . "486351"^^ . "486351"^^ . "MKC-1PTNCI" .