"A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. (NCI04)NCI" . . "Adenovirus p53SYNCI" . "C2471"^^ . _:b644279 . "INGN-201CNNCI" . _:b644280 . _:b644278 . _:b644281 . _:b644277 . _:b644280 . _:b644279 . "Head and Neck cancer; Lip and oral cavity cancer; Oropharyngeal cancer"^^ . _:b644277 . _:b644278 . _:b644279 . "C1135129"^^ . "43016"^^ . "Ad5CMV-p53 Gene"^^ . "AdvexinBRNCI" . _:b644277 . "683550"^^ . _:b644278 . "Pharmacologic Substance"^^ . "Ad5CMV-p53_Gene"^^ . _:b644280 . _:b644280 . _:b644281 . _:b644281 . _:b644281 . "Ad-p53ABNCI" . . "Ad5CMV-p53 GenePTNCI" . "Ad5CMV-p53 Gene"^^ . _:b644277 . . "Ad5CMV p53 GeneSYNCI" . _:b644278 . "p53 Gene, Ad5CMVSYNCI" . _:b644279 . "43016"^^ . "Adeno-p53SYNCI" . "Virus"^^ . "RPR/INGN-201CNNCI" .