. "C2415"^^ . "42586"^^ . . "Oxonate, potassiumSYDTPNSC0028841" . "4R7FFA00RX"^^ . "Potassium OxonateSYNCI" . "The potassium salt of oxonate, an enzyme inhibitor that modulates 5- fluorouracil (5-FU) toxicity. Potassium oxonate inhibits orotate phosphoribosyltransferase, which catalyzes the conversion of 5-FU to its active or phosphorylated form, FUMP. Upon oral administration, Oxonate is selectively distributed to the intracellular sites of tissues lining the small intestines, producing localized inhibitory effects within the gastrointestinal tract. As a result, 5-FU associated gastrointestinal toxic effects are reduced and the incidence of diarrhea or mucositis is decreased in 5-FU related therapy.NCI" . "Potassium oxonateSYDTPNSC0028841" . "Oteracil PotassiumPTNCI" . "42586"^^ . . "Oxonate PotassiumSYNCI" . "Inorganic Chemical"^^ . "Oteracil Potassium"^^ . "OXOABNCI" . "Potassium_Oxonate"^^ . "Pharmacologic Substance"^^ . "2207-75-2"^^ . "Oxonic Acid, Potassium SaltSYNCI" . . "Oteracil Potassium"^^ . "28841"^^ . "C0393003"^^ . "C4H2N3O4.K"^^ . "FDA"^^ . "OTERACIL POTASSIUMPTFDA4R7FFA00RX" .