. "39141"^^ . . "C235"^^ . "C19H20N8O5"^^ . . "Aminopterin"^^ . "Aminopterin"^^ . "54-62-6"^^ . "C0002583"^^ . "39141"^^ . "Aminopterin"^^ . "4-Amino-PGASYNCI" . "Pharmacologic Substance"^^ . . "AminopterinPTDCP02633" . "AminopterinPTNCI" . "APGASYDTPNSC0000739" . . "AMINOPTERINPTFDAJYB41CTM2Q" . "CHEBI:22526"^^ . "Amino Acid, Peptide, or Protein"^^ . "4-Aminofolic acidSYDTPNSC0000739" . "AminopterinSYDTPNSC0000739" . "FDA"^^ . "4-Aminofolic AcidSYNCI" . "aminopterinPTNCI-GLOSSCDR0000045171" . "4-Aminopteroylglutamic acidSYDTPNSC0000739" . "4-Aminopteroylglutamic AcidSYNCI" . "JYB41CTM2Q"^^ . "A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)NCI" . "Aminopteroylglutamic AcidSYNCI" . . . "An anticancer drug that belongs to the family of drugs called antimetabolites.NCI-GLOSS" . "739"^^ . "APGAABNCI" .