"Pharmacologic Substance"^^ . "Camptothecin_Sodium"^^ . "Organic Chemical"^^ . "Camptothecin Sodium SaltSYNCI" . . "Camptothecin sodiumSYDTPNSC0100880" . . "Camptothecin, sodium saltSYDTPNSC0100880" . "Camptothecin Sodium"^^ . "Sodium camptothecinSYDTPNSC0100880" . "Camptothecin Sodium"^^ . "C2344"^^ . "Camptothecin SodiumPTNCI" . . "The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04)NCI" . "100880"^^ . "C1516156"^^ .