"Dihydrofolate Reductase Inhibitor"^^ . . "C2153"^^ . . "DHFR InhibitorSYNCI" . "C2911817"^^ . "Dihydrofolate Reductase InhibitorPTNCI" . "Any substance that inhibits dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential reaction for de novo glycine and purine synthesis. Inhibition of dihydrofolate reductase interferes with DNA and protein synthesis.NCI" . "Dihydrofolate_Reductase_Inhibitor"^^ . "Chemical Viewed Functionally"^^ . "Dihydrofolate Reductase Inhibitor"^^ .