. . "GCS InhibitorsSYNCI" . "Any substance that inhibits glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme that catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine, the rate-limiting step in the biosynthesis of glutathione. Since glutathione is critical in protecting cells against oxidative stress, its depletion results in free radical-induced apoptosis.NCI" . "Gamma-Glutamylcysteine_Synthetase_Inhibitor"^^ . "Gamma-Glutamylcysteine Synthetase Inhibitor"^^ . "C1517431"^^ . "C2130"^^ . "Gamma-Glutamylcysteine Synthetase Inhibitor"^^ . "Glutathione Synthesis InhibitorsSYNCI" . "Gamma-Glutamylcysteine Synthetase InhibitorPTNCI" . "Glutamate-cysteine Ligase InhibitorSYNCI" . "Chemical Viewed Functionally"^^ .