"IAP Family GenePTNCI" . "IAP Family Gene"^^ . "IAP_Family_Gene"^^ . . _:b680950 . "IAP Family Gene"^^ . _:b680950 . _:b680950 . . _:b680950 . "C1334073"^^ . "IAP Family Protein"^^ . "Mammalian IAP Family Genes encode conserved Inhibitors of Apoptosis Proteins with an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)NCI" . "C20938"^^ . "Gene or Genome"^^ .