_:b652763 . "Renal Cell Carcinoma"^^ . "C1844"^^ . "temsirolimusPTNCI-GLOSSCDR0000434624" . _:b751909 _:b652763 . _:b630574 . . _:b652763 . _:b751908 _:b652762 . . _:b733495 _:b751908 . "A drug used to treat advanced renal cell carcinoma (a type of kidney cancer). It is also being studied in the treatment of other types of cancer. Temsirolimus blocks a protein involved in cell division, and may kill cancer cells. It is a type of rapamycin analog and a type of serine/threonine kinase inhibitor.NCI-GLOSS" . . "Acute lymphoblastic leukemia; Acute myeloid leukemia; Breast cancer; Chronic lymphocytic leukemia; Chronic myelogenous leukemia; Chronic myelomonocytic leukemia; Endometrial cancer;"^^ . . _:b751910 _:b652764 . _:b652766 . "162635-04-3"^^ . "Rapamycin Analog CCI-779SYNCI" . "43369"^^ . "Temsirolimus"^^ . _:b751911 _:b652765 . "FDA"^^ . _:b652764 . "624KN6GM2T"^^ . _:b652764 . _:b652765 . "Carbohydrate"^^ . _:b652762 . _:b652765 . _:b630574 _:b733495 . "Rapamycin AnalogSYNCI" . _:b652764 . "CCI-779 Rapamycin AnalogSYNCI" . . _:b652766 . _:b652766 . "C1707080"^^ . "CCI-779PTDCP50522" . _:b751911 _:b751912 . "CCI-779CNNCI" . _:b652762 . _:b751908 _:b751909 . _:b652765 . "C56H87NO16"^^ . _:b751909 _:b751910 . "Advanced renal cell carcinoma"^^ . "CCI-779"^^ . _:b751910 _:b751911 . "43369"^^ . _:b652763 . _:b751912 _:b652766 . "TemsirolimusPTNCI" . "Temsirolimus"^^ . "An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.NCI" . "ToriselBRNCI" . "Cell Cycle Inhibitor 779SYNCI" . "ToriselPTNCI-GLOSSCDR0000554353" . _:b733495 . _:b630574 . _:b751912 . "CCI-779PTNCI-GLOSSCDR0000046195" . _:b652762 . "TEMSIROLIMUSPTFDA624KN6GM2T" . "683864"^^ . "42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycinSNNCI" .