"BMS-186716-01CNNCI" . "BMS-186716CNNCI" . . . "Omapatrilat"^^ . "Organic Chemical"^^ . "OmapatrilateSYNCI" . "FDA"^^ . . "C1782"^^ . . "36NLI90E7T"^^ . "OMAPATRILATPTFDA36NLI90E7T" . "A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation.NCI" . "VanlevBRNCI" . . "167305-00-2"^^ . . "C0663645"^^ . "OmapatrilatPTNCI" . "C19H24N2O4S2"^^ . "(4S,7S,10aS)-Octahydro-4-((S)-.Alpha.-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic AcidSNNCI" . "Omapatrilat"^^ . "Pharmacologic Substance"^^ . "Omapatrilat"^^ .