"190070"^^ . _:b726341 . _:b796636 _:b796637 . _:b726339 . "p21 K-Ras Protein"^^ . "KRAS2SYNCI" . "c-K-RasSYNCI" . _:b796637 _:b796638 . _:b796638 _:b726341 . "c-K-Ras ProteinSYNCI" . _:b796639 _:b726342 . _:b744015 . "p21_K-Ras_Protein"^^ . _:b641435 . _:b726341 . "2 isoforms made by alternate splicing"^^ . _:b641435 _:b744015 . _:b796636 _:b726339 . _:b796637 _:b726340 . _:b726340 . "KRASSYNCI" . "K-Ras p21 ProteinSYNCI" . "K-Ras-2 ProteinSYNCI" . . "Ki-RasSYNCI" . _:b796639 . "p21 K-Ras Protein"^^ . "C0079973"^^ . _:b726342 . "K-Ras-2 p21SYNCI" . _:b726339 . "K-Ras 2ASYNCI" . "Enzyme"^^ . "p21 K-Ras ProteinPTNCI" . _:b726342 . "P01116"^^ . "Amino Acid, Peptide, or Protein"^^ . . _:b726342 . _:b744015 _:b796636 . _:b726340 . "C17383"^^ . _:b726339 . "p21 K-RAS protein is encoded by the K-RAS gene. Two KRAS isoforms are produced by alternative splicing. RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form. RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein. This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors. KRAS is involved in malignancy much more often than is HRAS. (from OMIM 190070, SWISS-PROT P01116, P01118, and NCI)NCI" . _:b726341 . _:b796638 _:b796639 . _:b726340 . _:b641435 .