_:b763842 _:b677052 . _:b763831 _:b763832 . _:b677055 . _:b677051 . _:b730509 . _:b763836 _:b677046 . _:b763843 _:b677053 . "Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activated GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation."^^ . _:b677048 . _:b763839 _:b677049 . _:b763837 _:b677047 . _:b677049 . _:b763838 _:b677048 . _:b677049 . _:b677050 . _:b763834 _:b677044 . _:b677051 . "NR3C1SYNCI" . _:b677050 . _:b763835 _:b677045 . _:b633239 . _:b677044 . _:b763833 _:b677043 . _:b677061 . _:b677051 . _:b763832 _:b677042 . _:b763847 _:b677057 . _:b677045 . _:b677048 . _:b763846 _:b677056 . _:b677055 . _:b677046 . _:b677049 . _:b763831 _:b677041 . _:b677042 . _:b677047 . _:b677054 . . _:b677055 . _:b763850 _:b677060 . _:b677052 . _:b677054 . _:b677043 . _:b763851 _:b677061 . _:b763849 _:b677059 . _:b677053 . _:b677043 . _:b763848 _:b677058 . _:b677042 . _:b677059 . "GRSYNCI" . _:b677057 . _:b677045 . _:b677043 . "Glucocorticoid receptor (777 aa, ~86 kDa) is encoded by the human NR3C1 gene. This protein plays a role in both chromatin remodeling and transcriptional regulation.NCI" . . _:b677044 . _:b633239 _:b730509 . _:b763847 _:b763848 . _:b677041 . _:b677061 . _:b763844 _:b763845 . "Glucocorticoid_Receptor"^^ . _:b763839 _:b763840 . _:b677046 . _:b677060 . _:b763845 _:b763846 . _:b677047 . _:b677059 . "C0034809"^^ . _:b763846 _:b763847 . _:b677044 . _:b677058 . "P04150"^^ . _:b677060 . _:b677057 . _:b677045 . _:b763841 _:b763842 . "Nuclear Receptor Subfamily 3, Group C, Member 1SYNCI" . _:b763840 _:b763841 . _:b677058 . _:b677056 . "C17071"^^ . _:b763843 _:b763844 . _:b677041 . "Nuclear Receptor Subfamily 3 Group C Member 1SYNCI" . _:b763842 _:b763843 . _:b763835 _:b763836 . _:b677048 . "Receptor"^^ . "Glucocorticoid Receptor, LymphocyteSYNCI" . _:b763834 _:b763835 . . "138040"^^ . _:b677058 . _:b763833 _:b763834 . _:b677059 . _:b763832 _:b763833 . "Glucocorticoid Receptor"^^ . _:b677056 . _:b677046 . _:b763838 _:b763839 . _:b677057 . "Glucocorticoid ReceptorPTNCI" . _:b763844 _:b677054 . _:b677050 . _:b763836 _:b763837 . _:b677056 . _:b677053 . _:b763845 _:b677055 . _:b633239 . _:b763850 _:b763851 . _:b677047 . _:b763837 _:b763838 . _:b677042 . _:b763849 _:b763850 . _:b677060 . _:b763848 _:b763849 . _:b763851 . _:b677061 . _:b677041 . _:b677052 . _:b763841 _:b677051 . "Amino Acid, Peptide, or Protein"^^ . "Glucocorticoid Receptor"^^ . _:b763840 _:b677050 . _:b677053 . _:b677052 . _:b730509 _:b763831 . _:b677054 .