"C0388638"^^ . "A substance that is being studied in the treatment of cancer. It is obtained from a marine organism.NCI-GLOSS" . "Dehydrodemnin BSYNCI" . "aplidinePTNCI-GLOSSCDR0000046693" . . "C1689"^^ . "DDBABNCI" . "460052"^^ . "PlitidepsinPTNCI" . "638719"^^ . "AplidineSYNCI" . "Aplidine"^^ . "AplidinePTDCP50576" . "FDA"^^ . "Dehydrodidemnin BSYNCI" . "A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.NCI" . "Lymphomas; melanomas; neuroendocrine tumors."^^ . "460052"^^ . . "Plitidepsin"^^ . . "PLITIDEPSINPTFDAY76ID234HW" . "Plitidepsin"^^ . "Y76ID234HW"^^ . . "APLDABNCI" . . "Antibiotic"^^ . "AplidinBRNCI" . "Amino Acid, Peptide, or Protein"^^ . "N-[1-(1,2-Dioxopropyl)-L-prolyl]didemnin ASNNCI" . "137219-37-5"^^ .