"Pharmacologic Substance"^^ . "TallimustinePTNCI" . "71193OXG6S"^^ . "Organic Chemical"^^ . . "Tallimustine"^^ . "115308-98-0"^^ . "Tallimustine"^^ . "Tallimustine"^^ . "C1603"^^ . "42145"^^ . "PNU-152241CNNCI" . "C0286890"^^ . "TALLIMUSTINEPTFDA71193OXG6S" . "FDA"^^ . . "A benzoyl mustard derivative of the antiviral agent distamycin A with potential antineoplastic activity. Tallimustine selectively binds to A-T rich regions in the minor groove of DNA and alkylates at the N3 position of adenine in a highly sequence-specific manner. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. Moreover, unlike other clinical nitrogen mustards, tallimustine does not carry out guanine-N7 alkylation in the major groove of DNA, which may lead to a high selectivity of action.NCI" . . "FCE 24517CNNCI" . "C32H38Cl2N10O4"^^ . . "42145"^^ .