. "PIBROZELESINPTFDAIHK933KCIC" . "Antibiotic"^^ . "KW_2189"^^ . "42429"^^ . "42429"^^ . "Pibrozelesin"^^ . "Pibrozelesin"^^ . "PibrozelesinPTNCI" . "Organic Chemical"^^ . "IHK933KCIC"^^ . "Duocamycin B2 AnalogSYNCI" . "C1542"^^ . "FDA"^^ . "KW2189PTNCI-GLOSSCDR0000046042" . . "154889-68-6"^^ . "C0254093"^^ . "Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic Acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methy-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7,-trimethoxy-1H-indol-2-yl)carbonyl)-, Methyl Ester (S)SNNCI" . . "A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.NCI" . "Pharmacologic Substance"^^ . "A semisynthetic anticancer drug that is a type of antitumor antibiotic.NCI-GLOSS" . "KW 2189CNNCI" . "C32H36BrN5O8"^^ . . "KW-2189CNNCI" .