"ZosynBRNCI" . . "C0250480"^^ . "Piperacillin-TazobactamPTNCI" . "Piperacillin-Tazobactam"^^ . "piperacillin-tazobactamPTNCI-GLOSSCDR0000046674" . "A drug combination that is used to treat infection in people with cancer. Piperacillin is a synthetic penicillin; tazobactam enhances the effectiveness of piperacillin.NCI-GLOSS" . . "Antibiotic"^^ . "A combination formulation of the antibiotic piperacillin and the beta-lactamase inhibitor tazobactam with antibacterial activity. Piperacillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. Tazobactam, a penicillanic acid sulfone derivative, irreversibly binds to and inhibits bacterial beta-lactamase at or near its active site, thereby preventing the destruction of the beta-lactamase susceptible piperacillin by this bacterial enzyme.NCI" . "43437"^^ . "Organic Chemical"^^ . "PIPER/TAZOSYNCI" . "43437"^^ . "C1530"^^ . . "Piperacillin-Tazobactam"^^ . "Piperacillin-Tazobactam"^^ . "Piperacillin/TazobactamSYNCI" .