"Liarozole_Fumarate"^^ . "Liarozole Fumarate"^^ . . "Organic Chemical"^^ . . "C0245820"^^ . "R85246CNNCI" . . "(+-)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole Fumarate (2:3)SNNCI" . "Liarozole Fumarate"^^ . "41252"^^ . . "1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, (+-)-, (E)-2-butenedioate (2:3)SNNCI" . "145858-52-2"^^ . "Liarozole FumaratePTNCI" . . "41252"^^ . "2C17H13ClN4.3C4H4O4"^^ . "FDA"^^ . "The orally active fumarate salt of the benzimidazole derivative liarozole with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.NCI" . "C1524"^^ . "Pharmacologic Substance"^^ . "LIAROZOLE FUMARATEPTFDA91W7VLK7J3" . "91W7VLK7J3"^^ .