"I66ZZ0ZN0E"^^ . "TROGLITAZONEPTFDAI66ZZ0ZN0E" . "TroglitazonePTDCP09341" . "PrelayBRNCI" . . "RomozinBRNCI" . "Pharmacologic Substance"^^ . "FDA"^^ . "RezulinBRNCI" . "CHEBI:9753"^^ . "An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04)NCI" . "CS-045CNNCI" . "C1522"^^ . "C0245514"^^ . "Organic Chemical"^^ . . "5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl-2,4-thiazolidinedioneSNNCI" . "TroglitazonePTNCI" . . "Troglitazone"^^ . "42706"^^ . . . "Troglitazone"^^ . "42706"^^ . "Troglitazone"^^ . "CI-991CNNCI" . "97322-87-7"^^ . . "5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedioneSNNCI" .