"A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)NCI" . "LAMIVUDINEPTFDA2T8Q726O95" . "HIV infections; HTLV-1-associated adult T-cell leukemia and lymphoma"^^ . . "42593"^^ . "C1471"^^ . . "lamivudinePTNCI-GLOSSCDR0000045519" . "3'-Thia-2',3'-dideoxycytidineSNNCI" . "42593"^^ . "Chronic hepatitis B; HIV infection"^^ . "Pharmacologic Substance"^^ . "2',3'-Dideoxy-3'-thiacytidineSNNCI" . "Lamivudine"^^ . "Lamivudine"^^ . "EpivirBRNCI" . "3TCABNCI" . "CHEBI:63577"^^ . . "FDA"^^ . "4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinoneSNNCI" . "Nucleic Acid, Nucleoside, or Nucleotide"^^ . "LamivudinePTNCI" . "GR109714XCNNCI" . "C8H11N3O3S"^^ . "134678-17-4"^^ . . "A drug used to treat infection caused by viruses.NCI-GLOSS" . "Lamivudine"^^ . "2T8Q726O95"^^ . "C0209738"^^ . "(-)-BCH-189CNNCI" . . .