"A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called differentiating agents.NCI-GLOSS" . "536018"^^ . "Lipid"^^ . "Sodium 4-phenylbutyrateSYDTPNSC0657802" . _:b725198 . "C0718066"^^ . _:b725198 . _:b725199 . . "536018"^^ . _:b725199 . . "SPB11BRNCI" . "_4-Phenylbutyrate"^^ . "SODIUM PHENYLBUTYRATEPTFDANT6K61736T" . _:b728914 _:b796249 . _:b796253 . "FDA"^^ . "C1440"^^ . _:b725199 . _:b796252 _:b796253 . _:b740165 . _:b725202 . "1716-12-7"^^ . "Adjunctive therapy for urea cycle disorders involving deficiencies of carbamoylphosphate synthetase; ornithine transcarbamylase; or argininosuccinic acid synthetase; S-S and S-C sickle cell disease; S-thalassemia hemoglobinopathy"^^ . "Sodium PhenylbutyratePTDCP31743" . _:b740165 _:b728914 . _:b796249 _:b725198 . . _:b725200 . _:b725200 . _:b725198 . "phenylbutyratePTNCI-GLOSSCDR0000045402" . _:b796253 _:b725202 . "Sodium 4-PhenylbutyrateSNNCI" . _:b796250 _:b725199 . "Sodium Phenylbutyrate"^^ . _:b725201 . _:b641408 . "Phenylbutyrate SodiumSYNCI" . . _:b796252 _:b725201 . _:b725202 . "BuphenylBRNCI" . _:b796251 _:b725200 . "NT6K61736T"^^ . "C10H11O2.Na"^^ . . _:b725200 . _:b725201 . _:b725201 . _:b641408 . _:b725202 . "Sodium PhenylbutyratePTNCI" . _:b641408 _:b740165 . "The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.NCI" . "4-Phenylbutyric Acid, Sodium SaltSNNCI" . "Refractory solid tumors; myelodysplastic syndromes; chronic myelomonocytic leukemia; acute myeloid leukemia; advanced colorectal adenocarcinoma"^^ . _:b796251 _:b796252 . "657802"^^ . "Sodium Phenylbutyrate"^^ . _:b796250 _:b796251 . "Pharmacologic Substance"^^ . _:b728914 . _:b796249 _:b796250 .