. "Lobaplatin"^^ . "1,2-diammino-methy lcyclobutane-platinum (II) lactateSNNCI" . "C6H14N2.C3H4O3.Pt"^^ . "A third-generation, water-soluble platinum compound with potential antineoplastic activity. Lobaplatin forms highly reactive, charged, platinum complexes that bind to nucleophilic groups such as GC- and AG-rich sites in DNA, inducing intrastrand DNA cross-links. These cross-links will ultimately result in induction of apoptosis and cell growth inhibition. Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.NCI" . "lobaplatinPTNCI-GLOSSCDR0000045385" . "C1434"^^ . "A substance that contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.NCI-GLOSS" . "Pharmacologic Substance"^^ . "Lobaplatin"^^ . "21034513"^^ . "135558-11-1"^^ . "LobaplatinPTNCI" . "41669"^^ . . "OX5XK1JD8C"^^ . . "FDA"^^ . "C0165747"^^ . "Inorganic Chemical"^^ . . "LOBAPLATINPTFDAOX5XK1JD8C" . "D-19466CNNCI" . "41669"^^ . "Lobaplatin"^^ .