"C0164550"^^ . "FDA"^^ . "Rogletimide"^^ . "Pharmacologic Substance"^^ . "41461"^^ . "RogletimidePTDCP31687" . . . "619778"^^ . "ROGLETIMIDEPTFDA14P4QR28QF" . "Rogletimide"^^ . "Organic Chemical"^^ . "Rogletimide"^^ . . "41461"^^ . "PyridoglutethimideSYDTPNSC0619778" . "14P4QR28QF"^^ . . "PyridoglutethimideSYNCI" . "C12H14N2O2"^^ . "C1427"^^ . "92788-10-8"^^ . "An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a cytochrome P450 family enzyme found in many tissues and the key enzyme in the oxidative aromatization process of androgens to estrogens. In estrogen-dependent cancers, the inhibition of aromatase by this agent leads to a reduction in the synthesis of estrogen, thereby inhibiting estrogen-mediated signal transduction and consequently reducing tumor cell growth. In addition, rogletimide also inhibits enzymes that catalyzing conversion of cholesterol to corticosteroids.NCI" . "RogletimidePTNCI" .