"C0127565"^^ . "C1390"^^ . . "Merbarone"^^ . . "40220"^^ . . "MerbaroneSYDTPNSC0336628" . "Merbarone"^^ . "336628"^^ . "A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes.NCI" . "Pharmacologic Substance"^^ . "Merbarone"^^ . "40220"^^ . "MerbaronePTNCI" . "Organic Chemical"^^ .