"Organic Chemical"^^ . "Liposomal Neodecanoic Acid Platinum ComplexSYNCI" . _:b686990 . "Liposomal-Cisplatin AnalogueSYNCI" . "A synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-stranded DNA cross-linkings and inhibiting DNA synthesis, which results in tumor cell cytotoxicity. Because DNA mismatch-repair (MMR) complexes do not recognize DACH-platinum adducts, DNA repair mechanisms are inhibited, overcoming limitations observed with other platinum-based agents. In addition, the liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile.NCI" . . "43010"^^ . "Liposomal-Cisplatin_Analogue"^^ . "Liposomal-Entrapped Cis-Bis-Neodecanoate-trans-R,R-1,2-Diaminocyclohexane Platinum (II)SNNCI" . "114488-24-3"^^ . "Pharmacologic Substance"^^ . _:b686992 . "AroplatinBRNCI" . _:b686992 . "43010"^^ . . "L-NDDPABNCI" . _:b686992 . "Liposomal NDDPPTNCI" . "Liposomal NDDP"^^ . _:b686990 . . _:b686990 . "C0125061"^^ . "Liposomal NDDP"^^ . _:b686991 . _:b686991 . . "C1383"^^ . _:b686990 . _:b686991 . _:b686991 . _:b686992 .