"Organic Chemical"^^ . "epipodophyllotoxinPTNCI-GLOSSCDR0000044822" . "Pharmacologic Substance"^^ . . . "Epipodophyllotoxin Compound"^^ . "Epipodophyllotoxin CompoundPTNCI" . "C0086243"^^ . "Epipodophyllotoxin Compound"^^ . "Epipodophyllotoxin_Compound"^^ . "An alkaloid isolated or derived synthetically from Podophyllum peltatum that can bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.NCI" . . "A substance being studied in the treatment of some types of cancer. Epipodophyllotoxin is extracted from the mandrake root Podophyllum peltatum. It is a type of topoisomerase inhibitor.NCI-GLOSS" . . "C1331"^^ .