. . . "8R78F6L9VO"^^ . "FDA"^^ . "A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraines.MSH2002_06_01" . . "103628-46-2"^^ . "C14H21N3O2S"^^ . "Organic Chemical"^^ . "SumatriptanPTNCI" . "Sumatriptan"^^ . . . "A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.NCI" . "SUMATRIPTANPTFDA8R78F6L9VO" . "Sumatriptan"^^ . "C1240"^^ . "C0075632"^^ . "Pharmacologic Substance"^^ . "Sumatriptan"^^ . . "CHEBI:10650"^^ .