"C1219"^^ . "Ketorolac"^^ . "A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.NCI" . "40569"^^ . "FDA"^^ . "KetorolacPTNCI" . "C0073631"^^ . "YZI5105V0L"^^ . "KETOROLACPTFDAYZI5105V0L" . . . "Ketorolac"^^ . . . "KetorolacPTDCP30559" . "74103-06-3"^^ . "Organic Chemical"^^ . . "Ketorolac"^^ . "Pharmacologic Substance"^^ . "C15H13NO3"^^ . "ketorolacPTNCI-GLOSSCDR0000045305" . . "40569"^^ .