"A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells, reduced pimonidazole binds to thiol-containing proteins. The resulting complexes accumulate in hypoxic tumors, thereby depleting radioprotective thiol compounds and sensitizing tumor cells to be more susceptible for radiation treatment.NCI" . "PimonidazolePTNCI" . "PD 126675CNNCI" . "C11H18N4O3"^^ . "C1196"^^ . "Pimonidazole"^^ . "46JO4D76R2"^^ . "70132-51-3"^^ . "1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)-SNNCI" . . "Organic Chemical"^^ . "Pimonidazole"^^ . "Pimonidazole"^^ . . "Indicator, Reagent, or Diagnostic Aid"^^ . "380540"^^ . "C0071072"^^ . "40356"^^ . "PimonidazoleSYDTPNSC0380540" . . "Ro 03-8799CNNCI" . . "40356"^^ . "PIMONIDAZOLEPTFDA46JO4D76R2" . "FDA"^^ . .