_:vb698575 . . _:vb698574 . "EloxatineFBNCI" . "oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)SNNCI" . "Oxaliplatin"^^ . "Diaminocyclohexane OxalatoplatinumSYNCI" . "RP-54780CNNCI" . "DacplatFBNCI" . "OxalatoplatinumSYNCI" . "42374"^^ . _:vb698575 . "SR-96669CNNCI" . _:vb698576 . "OxaliplatinPTNCI" . . _:vb698574 . "Liver metastases; medulloblastoma; non-small cell lung cancer; ovarian epithelial cancer; pancreatic cancer; small bowel adenocarcinoma; supratentorial primitive neuroectodermal tumor; unspecified solid tumors"^^ . "Oxaliplatin"^^ . . _:vb698575 . "[SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinumSNNCI" . _:vb698574 . "OxalatoplatinumSYDTPNSC0266046" . "RP 54780SYDTPNSC0266046" . "266046"^^ . "trans-l diaminocyclohexane oxalatoplatinumSNNCI" . "DacotinFBNCI" . "OxaliplatinSYDTPNSC0266046" . "Metastatic colorectal cancer; ovarian cancer"^^ . "OxalatoplatinSYDTPNSC0266046" . "1-OHPSYDTPNSC0266046" . "FDA"^^ . "C1181"^^ . "Pharmacologic Substance"^^ . "CHEBI:31941"^^ . "EloxatinPTNCI-GLOSSCDR0000413944" . "ELOXATINSYDTPNSC0266046" . "trans-l DACH oxalatoplatinumSNNCI" . . _:vb698574 . "DACPLATSYDTPNSC0266046" . "C8H14N2O4Pt"^^ . "A drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.NCI-GLOSS" . _:vb698575 . "Oxaliplatin"^^ . "EloxatinBRNCI" . _:vb698577 . "Atypical teratoid rhabdoid tumor; cervical cancer; colorectal cancer; endometrial cancer; esophageal cancer; gastric cancer; gastroesophageal junction adenocarcinoma; glioblastoma multiforme"^^ . "An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)NCI" . _:vb698577 . "04ZR38536J"^^ . "C0069717"^^ . "61825-94-3"^^ . _:vb698576 . "42374"^^ . . "oxalato (1R,2R-cyclohexanediamine)platinum(II)SNNCI" . _:vb698576 . _:vb698577 . "oxaliplatinPTNCI-GLOSSCDR0000045465" . . "[(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinumSNNCI" . . "JM-83CNNCI" . "1-OHPABNCI" . _:vb698576 . "OxalatoplatinSYNCI" . _:vb698577 . "OXALIPLATINPTFDA04ZR38536J" .