"353451"^^ . "40221"^^ . . "85622-95-3"^^ . "AzolastoneSYDTPNSC0353451" . "Mitozolomide"^^ . "40221"^^ . "FDA"^^ . "MITOZOLOMIDEPTFDAE3U7286V3W" . "Mitozolomide"^^ . "C1166"^^ . "Pharmacologic Substance"^^ . . "A prodrug of imidazotetrazine alkylating agent with antineoplastic property. Mitozolomide undergoes ring opening upon the nucleophilic attack at C-4 by an activated molecule of water within the major groove of DNA. The resulting bioactive mono-alkyltriazene species are capable of alkylating nucleophilic residues in the immediate vicinity such as N-7 and/or O-6 sites of guanine, thereby causes intra- or inter-stranded DNA cross-links and trigger apoptosis.NCI" . "Mitozolomide"^^ . "C0066618"^^ . "MitozolomidePTNCI" . "Organic Chemical"^^ . "C7H7ClN6O2"^^ . "E3U7286V3W"^^ . . . "imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxoSNNCI" . "Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo-SYDTPNSC0353451" . "MitozolomideSYDTPNSC0353451" . "AzolastoneBRNCI" .