"Organic Chemical"^^ . "19494"^^ . . "DDMPABNCI" . . . "Metoprine"^^ . "7364"^^ . "Pharmacologic Substance"^^ . "Metoprine"^^ . "C0066142"^^ . "2L9RKX796Q"^^ . "7761-45-7"^^ . "C1161"^^ . "Metoprine"^^ . "C11H10Cl2N4"^^ . "MetoprinePTNCI" . "FDA"^^ . . "A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04)NCI" . "39206"^^ . "METOPRINEPTFDA2L9RKX796Q" . "BW 197USYDTPNSC0007364" . . "39206"^^ . "BW 197UCNNCI" .