. "G162GK9U4W"^^ . . "Pharmacologic Substance"^^ . "leflunomidePTNCI-GLOSSCDR0000045436" . "FDA"^^ . "4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-SNNCI" . "A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)NCI" . "Organic Chemical"^^ . "42253"^^ . "LeflunomidePTNCI" . . "SU101CNNCI" . "AravaBRNCI" . "75706-12-6"^^ . "An anticancer drug that works by inhibiting a cancer cell growth factor.NCI-GLOSS" . "677411"^^ . "C1128"^^ . "SU101SYNCI-GLOSSCDR0000046000" . . "Leflunomide"^^ . . "LeflunomideSYDTPNSC0677411" . "C12H9F3N2O2"^^ . "Leflunomide"^^ . "C0718644"^^ . . "LEFLUNOMIDEPTFDAG162GK9U4W" . "42253"^^ . . "Leflunomide"^^ . "CHEBI:6402"^^ .