"42927"^^ . "Staphylococcal Enterotoxin APTNCI" . "C0059385"^^ . . "C1083"^^ . "Staphylococcal Enterotoxin A"^^ . "37337-57-8"^^ . "Amino Acid, Peptide, or Protein"^^ . "A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin A (SEA), a gram positive bacterial superantigen (SAg), is a potent stimulator of T-cell activation. SEA superantigen binds directly to class II major histocompatibility complex (MHC) molecules and to the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEA, both CD4+ and CD8+ cells proliferate, secrete cytokines, and demonstrate enhanced cytotoxic activity against a broad range of antigens. Vaccination with the SEA protein, administered by direct transfection into tumor cells, may elicit a non-specific cytotoxic T-cell (CTL) response and result in decreased tumor cell growth.NCI" . "SEAABNCI" . "Staphylococcal Enterotoxin A"^^ . . . . "Immunologic Factor"^^ . "Staphylococcal_Enterotoxin_A"^^ . "42927"^^ .