. "ABT-414CNNCI" . "EGFR Inhibitor ABT-414PTNCI" . "EGFR Inhibitor ABT-414"^^ . "C105612"^^ . "EGFR Inhibitor ABT-414"^^ . "747249"^^ . "747249"^^ . "Pharmacologic Substance"^^ . . "An epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon intravenous infusion, ABT-414 inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase overexpressed in certain tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.NCI" .