"Organic Chemical"^^ . "Fadrozole HydrochloridePTNCI" . "C1044"^^ . . . "AfemaFBNCI" . "102676-31-3"^^ . . "Fadrozole Hydrochloride"^^ . "4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile MonohydrochloridePTDCP08932" . "FDA"^^ . "Fadrozole Hydrochloride"^^ . "41025"^^ . "CGS-16949ACNNCI" . "The hydrochloride salt of the nonsteroidal aromatase inhibitor fadrozole with potential antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, the final step in estrogen biosynthesis; the reduction in estrogen levels may inhibit growth in estrogen-dependent cancers. Aromatase, a member of the cytochrome P-450 superfamily, is found in many tissues; overexpression has been linked to the development of preneoplastic and neoplastic changes in breast tissue.NCI" . "C0917743"^^ . "Fadrozole_Hydrochloride"^^ . "ArensinFBNCI" . "4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile HydrochlorideSNNCI" . "H0Q44H4ECQ"^^ . . "Pharmacologic Substance"^^ . . "41025"^^ . "C14H13N3.HCl"^^ . "FADROZOLE HYDROCHLORIDEPTFDAH0Q44H4ECQ" . "102676-96-0"^^ .