"CL437179"^^ . "Bruton's Tyrosine Kinase Inhibitor ONO-4059SYNCI" . . "C102876"^^ . "BTK Inhibitor ONO-4059"^^ . "738477"^^ . "738477"^^ . "BTK Inhibitor ONO-4059PTNCI" . . "ONO-4059CNNCI" . "BTK Inhibitor ONO-4059"^^ . "Pharmacologic Substance"^^ . "An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.NCI" .